Set in San Francisco, the comedy revolves around Chyna Parks (China Anne McClain), an 11-year old musical prodigy who attends high school as part of the prestigious A.N.T. (Advanced Natural Talents) programme.

Starring rising talent 12-year-old China Anne McClain, the series depicts the new fish-out-of-water situation Chyna Parks and her fellow A.N.T.s. encounter in the sometimes daunting world of high school – three years earlier than expected.

In addition to McClain, the series stars Sierra McCormick as Olive Doyle, an A.N.T. with a photographic memory; Jake Short as Fletcher Quimby, an artistic genius and practical joker; Stefanie Scott as Lexi Reed, an overachieving cheerleader who is intimidated by Chyna; and Carlon Jeffery as Cameron Parks, Chyna's older brother who overcompensates in order to step out of his sister's shadow. Together they must find their place and make the most of their high school experience despite the lukewarm welcome from some high school students.

Recurring characters are Finesse Mitchell and Elise Neal as Chyna's parents, Darryl and Roxanne Parks; Zach Steel as Gibson, the A.N.T's school counselor, and Aedin Mincks as Angus, the computer genius.

The series pilot was written by Dan Signer (The Suite Life on Deck) and directed by Bob Koherr (Hannah Montana, Wizards of Waverly Place).